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Allgemeine Informationen




Genfamilie: Proteinkodierende Gene


Ort im Genom: Chromosom 11 (Band 11p15.5)


Proteinprodukt: Vorstufe des humanen Wachstumshormons (hGH), ein wichtiges Peptid, das zahlreiche physiologische Prozesse steuert.



Funktion
Das GH1-Gen kodiert für das Prohormon, welches in der Hypophyse zu hGH verarbeitet wird. Das produzierte Hormon wirkt auf Knochen, Muskeln und Fettgewebe, beeinflusst Stoffwechsel, Zellwachstum und Zellreparatur sowie die Regulation von Insulin und Glukose.



Genstruktur




Anzahl der Exons: 7


Länge des Protein-Codes: 191 Aminosäuren (ca. 22 kDa)


Regulatorische Regionen: Enthält Promotoren, Enhancer und Bindungsstellen für Transkriptionsfaktoren wie STAT5B, CREB und GATA2.



Genexpression


Haupttissue: Hypophyse (anterior lobe)


Sekundäre Expression: Leber, Muskelgewebe, Knochen, Fettgewebe und andere Organe, insbesondere in der Entwicklung.


Regulation: Durch negative Rückkopplung von GH-spitzenwerten, durch Insulin-ähnliche Wachstumsfaktoren (IGF-1) sowie durch hormonelle Einflüsse wie Cortisol und Thyroxin.



Klinische Relevanz


Mangelzustände:


- Wachstumshormonmangel bei Kindern → Längenwachstumsstörung, verminderte Muskelmasse.
- GH-Defizienz im Erwachsenenalter → Erhöhtes Risiko für kardiovaskuläre Erkrankungen und metabolische Syndrome.





Überproduktion:


- Acromegalie (bei Erwachsenen) bzw. Gigantismus (bei Kindern) → Überwachungen von Gliedmaßen, Gelenken, Herz, Leber und anderen Organen.



Genetische Mutationen:


- Verlustfunktion (z. B. Deletion oder Punktmutation) führt zu Wachstumsdepression.
- Gain-of-Function-Mutationen können zu Überproduktion führen.



Therapeutische Anwendungen




Recombinant hGH wird zur Behandlung von Wachstumshormonmangel eingesetzt, sowohl bei Kindern als auch Erwachsenen (z. B. bei bestimmten Formen des Untergewichtes oder Muskelschwäche).


Antagonisten und Inhibitoren: Im Rahmen der Behandlung von Acromegalie; Beispiele sind Somatostatin-Analogien (Octreotide), GH-Rezeptorblocker (Pegvisomant) sowie Tyrosinkinaseinhibitoren.



Forschungsperspektiven


CRISPR/Cas9-Editierung zur Korrektur von Mutationen im GH1-Gen.


Immuntherapie: Entwicklung von Monoklonalen Antikörpern gegen GH-Rezeptoren, um die Wirkung des Hormons gezielt zu modulieren.


Biomarker-Entwicklung: Nutzung von Genexpressionsprofilen zur Vorhersage von Therapieerfolgen bei Acromegalie.






Literaturhinweise




Bouchard, C., et al. J Clin Endocrinol Metab. 2023;108(2):e123–e135.


Zhang, Y., et al. Hum Mutat. 2024;45(7):1023-1035.





Das menschliche Wachstumshormon (GH), auch Somatotropin genannt, spielt eine zentrale Rolle bei der Regulation des Körperwachstums und des Stoffwechsels. Es wird in der Hypophyse produziert und wirkt auf verschiedene Gewebe, um Zellteilung, Proteinsynthese und Fettstoffwechsel zu steuern. Im Folgenden werden die genetischen Grundlagen sowie verwandte Gene, deren kartierte Phänotypen und Quellen für die Geninformation detailliert beschrieben.



Gene



Das Hauptgen, das das menschliche Wachstumshormon kodiert, heißt GH1 (Growth Hormone 1). Es liegt auf Chromosom 17q22-24. Die GH1-Genfamilie besteht aus mehreren homologen Kopien, von denen GH1 die einzige aktive Version ist, die ein funktionelles Hormon produziert. Das Gen enthält sieben Exons und wird durch mehrere Promotorregionen reguliert, die Transkriptionsfaktoren wie GHRH (Growth Hormone Releasing Hormone), somatostatin und andere intrazelluläre Signale ansprechen. Mutationen in diesem Gen können zu GH-Mangelzuständen oder GH-Superproduktion führen.



Genes and mapped phenotypes



Neben dem Hauptgen gibt es mehrere Gene, die mit der Regulation des Wachstumshormons verknüpft sind:





GHR (Growth Hormone Receptor) – Das Rezeptor-Gen liegt auf Chromosom 5q35. Mutationen können zu Laron-Syndrom führen, bei dem trotz normalem oder erhöhtem GH ein Anhaltsschwierigkeit im Wachstum vorliegt.


IGF1 (Insulin-like Growth Factor 1) – Dieses Gen befindet sich auf Chromosom 12p13. Die IGF1-Produktion wird durch GH stimuliert; Mutationen können zu Wachstumsdepressionen oder unregelmäßigem Wachstum führen.


GHRH (Growth Hormone Releasing Hormone) – Lokalisiert auf Chromosom 5q35, beeinflusst die Hypophyse die Freisetzung von GH. Fehlfunktionen resultieren in hypogonadistischen Zuständen und Wachstumsverzögerungen.


SOCS2 (Suppressor of Cytokine Signaling 2) – Auf Chromosom 12q24 liegt dieses Gen; es hemmt den GH-Signalweg. Mutationen können zu unkontrolliertem Wachstum und Tumoren führen.


POU1F1 (Pituitary-specific positive transcription factor 1) – Dieses Transkriptionsfaktor-Gen befindet sich auf Chromosom 6p21 und reguliert die Expression von GH, TSH und PRL. Mutationen können zu Wachstumsdepressionen, Hypothyreose und Milchproduktionseinschränkungen führen.



Die kartierten Phänotypen dieser Gene umfassen:

GROWTH HORMONE DEFICIENCY – verursacht durch Mutationen im GH1-Gen oder in der Regulierung.
LARON SYNDROM – durch GHR-Mutationen, führt zu einer hohen GH, aber niedrigen IGF1-Konzentration.
SLEEPING DISEASE – bei SOCS2-Defekten entsteht ein unkontrolliertes Wachstum und erhöhtes Krebsrisiko.
CHRYSALIS SYNDROME – POU1F1-Mutationen können Wachstumsdepressionen, Schilddrüsenunterfunktion und Milchproduktionseinschränkungen verursachen.



Gene sources



Die Gene werden hauptsächlich aus öffentlichen Datenbanken und wissenschaftlichen Publikationen extrahiert. Zu den wichtigsten Quellen gehören:



NCBI Gene – Enthält umfassende Informationen zu GH1, GHR, IGF1 und anderen verwandten Genen, inklusive Sequenzdaten, Transkriptionsfaktoren und klinischen Varianten.
OMIM (Online Mendelian Inheritance in Man) – Liefert detaillierte Beschreibungen der genetischen Erkrankungen, die mit dem Wachstumshormon-System verknüpft sind.
ClinVar – Enthält klinische Bewertungen von Mutationen im GH1-Gen sowie verwandten Genen und deren Auswirkungen auf das Wachstum.
Ensembl – Bietet genomische Datenbanken für die genaue Lokalisierung von Genen, exons, intronen und regulatorischen Elementen.




GeneCards – Gibt einen schnellen Überblick über Genfunktion, Proteininteraktionen und klinische Relevanz.



Zusammenfassend liefert die genetische Basis des menschlichen Wachstumshormons ein komplexes Netzwerk aus Genen, Rezeptoren und Signalwegen. Die kartierten Phänotypen verdeutlichen die klinischen Auswirkungen von Mutationen, während die genannten Datenbanken und Literaturquellen die notwendigen Informationen für Forschung und Diagnostik bereitstellen.

Aleisha Borden, 19 years

Whether Or Not you joined the swole life yesterday or have been grinding away in iron paradise for years, we salute your dedication to the craft. As long as there are still features to be made and PRs but to be smashed, the crew will keep hustling to ship top-notch physique wisdom. This problem helped me believe in myself, gained extra strength and sturdiness and dig deep within and conquer all adverse thoughts to proceed to push via.
One of those challenges is that these youngsters and caretakers typically require housing while participating within the outpatient train program. In our research, the youngsters and caretakers live in hospital-sponsored housing outside of the hospital. These children usually are not rehospitalized however are introduced in as residential outpatients. One nice importance and significance of the present research is that it presents evidence that oxandrolone, alone or together with train, is helpful. As such, one can then envision modifications of the design of this examine or program to fit non–Shriners Hospital settings. Modifications may embrace beginning the exercise program immediately after discharge (typically 2–3 months after burn) versus waiting for the 6 months postburn time point.
It is usually advised to keep away from taking Anavar right earlier than bedtime. Since it can provide an energy boost, it might intrude with your ability to fall asleep or disrupt your sleep high quality. It is finest to take Anavar in the course of the daytime or earlier than your exercises. Anavar can be taken with or without meals, relying on personal preference. Some customers favor taking it on an empty abdomen to maximize absorption, whereas others discover it extra comfortable to take with a light meal to avoid potential stomach upset. Nevertheless, understanding these factors can help you make informed choices and optimize the effectiveness of this compound.
Publish Cycle Remedy (PCT) comes into the image as quickly as the combined Anavar and Winstrol cycle concludes. Simply as it’s important to watch out on your health through the cycle, it’s equally essential to care for your hormonal stability after the routine ends. A well-planned PCT helps your physique normalize its hormonal state, making certain a stable transition from an enhanced state to normalcy. Considering a cycle that merges two performance enhancers like Anavar and Winstrol requires a bit of understanding about the two compounds. It’s like bringing together two completely different musical maestros on a single album.
Thus, we only see this tried in sure circumstances, corresponding to preparing for an important competition the place there could be strain to put excessive. Superior customers can prolong the length to eight weeks; nonetheless, this is not suggested. Andriol is the brand name for oral testosterone, also called testosterone undecanoate.
Regardless Of these differences, both substances necessitate cautious utilization in order to keep away from potential adverse effects. From a productivity standpoint, Anavar is well-regarded because of its capacity to spice up energy and power with out introducing significant weight gain. This characteristic makes it a super selection for those focusing on endurance somewhat than dimension, corresponding to boxers and cyclists.
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Nevertheless, it soon caught the attention of bodybuilders thinking about gaining lean and high-quality muscle mass and Anavar suited their wants with its anabolic and fat-burning properties. When contemplating the dosage and cycle info for Anavar (Oxandrolone) throughout a four-week cycle, it's essential to prioritize safety and cling to responsible usage. It is essential to seek the guidance of with a medical skilled or a certified healthcare provider earlier than beginning any steroid cycle. They can provide personalized guidance based on your particular person well being standing, objectives, and any potential contraindications. These trajectories of transformation make the midway level of an Anavar cycle a moment of serious milestones and motivation.
Anavar is formally classed as a schedule III controlled substance in the us However, there are companies who promote spinoff variations (compounds virtually identical) to anavar online. Nonetheless, when you do go down this route don’t buy from firms with poorly designed websites or ones which don’t listing their address, as you could get scammed. People additionally sell Anavar on the black market, which is where most people get it from. Lisa’s testimonial highlights the psychological and emotional impact that Anavar can have, demonstrating how it can serve as a catalyst for positive change past physical look. Additionally, Anvarol customers might not expertise the same diploma of muscle fullness or enlarged pumps as with Anavar, with the latter having superior glycogen-storing properties.
Each of those anabolic steroids has its own advantages and disadvantages, relying on individual goals and preferences. All The Time consult with a healthcare professional earlier than utilizing any steroid to ensure protected and effective use. When stacking Anavar with other steroids, all the time remember to be cautious and intently monitor your body’s response to prevent potential health dangers. Consulting with a healthcare skilled before beginning any steroid cycle is highly really helpful. In a nutshell, Post Cycle Remedy is a restoration period supposed to rehabilitate your body after a steroid cycle. It’s a crucial step towards safeguarding your total health, maintaining the positive aspects made in the course of the cycle, and guaranteeing you’re reset and ready for any future bodybuilding ventures. Bear In Mind, a responsible strategy in path of steroid use includes the phases earlier than, during, and importantly, after the cycle.

Zack Belgrave, 19 years

Scientific investigations reveal that Ipamorelin has the potential to raise the body’s natural progress hormone production by an impressive 30%. Given the pivotal role of progress hormone in fat metabolism, this elevation becomes crucial for attaining efficient fat loss. Properly, each of those chains of amino acids can result in elevated lean muscle mass, lower body fats, improved physique composition, improved immune system, and even higher cognitive perform. Another major focus is the Neurocognitive and Sleep ipamorelin effects. The ipamorelin peptide is understood to be linked to sleep high quality, and both GHRH and GHRP receptors are found within the mind. These studies are vital for defining the full spectrum of the sermorelin ipamorelin mixture benefits.
When deciding between Ipamorelin or Sermorelin, elements such as hormone deficiency, cardiovascular health, and specific wellness targets ought to be thought of to tailor the therapy to particular person needs. Selecting the appropriate peptide, whether or not Ipamorelin or Sermorelin, requires cautious consideration, session with a healthcare provider, and a thorough decision-making course of based on individual needs. Whereas Ipamorelin is generally well-tolerated, some potential unwanted facet effects could occur, especially with improper therapy or administration. Despite her demanding profession, Krysia places nice importance on sustaining a wholesome work-life steadiness.
Conversely, Sermorelin operates by immediately stimulating the pituitary gland to extend HGH manufacturing through its interaction with the expansion hormone-releasing hormone (GHRH) receptors. This distinctive mode of motion leads to a sustained elevation in HGH levels over an prolonged period, potentially offering advantages across numerous physiological capabilities. Potential unwanted side effects of Sermorelin embrace mild headaches, nausea, and minor reactions at the injection web site. Sermorelin features by stimulating the production of progress hormones within the body, which may result in hormone degree fluctuations, potentially leading to headaches and nausea. Sermorelin operates by directly stimulating the pituitary gland to increase the discharge of progress hormone, a vital think about cell regeneration and total growth.
Speak to an IVY RX provider to personalize your peptide protocol and begin your transformation. Both are powerful tools, but working with a peptide expert ensures you're selecting what’s greatest on your physique. Some clinics provide bundled peptide packages or reductions for long-term use. Our e-newsletter is bringing you the latest insights and news from the peptide world. Critically, this quick e-book will prevent lots of wasted cash and poorly frolicked (not to say preventing you from potential self-inflicted missteps). In both stacks, you could have Ipamorelin performing as the GHRP to extend HGH manufacturing by way of stimulation of the pituitary gland.
Both Ipamorelin and sermorelin work properly for individuals with development hormone deficiency or comparable symptoms. However these peptides could really help those who want higher muscle progress, fats loss plus improved sleep high quality. The compounds may also enhance vitality levels as well as pores and skin look.
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Both sermorelin and ipamorelin are thought-about secure for prolonged use when monitored by a medical supplier. Sermorelin may be most well-liked for longer protocols due to its alignment with natural hormone rhythms. This mixture can increase muscle development, improve weight reduction, and fight symptoms of cognitive decline such as memory lapses. Remedy with GHRH increased insulin like development factor 1 levels by 117 %(P.001), which remained throughout the physiological range, and decreased p.c body fats by 7.4%(P.001).
The paucity of data on this area suggests that further research into ipamorelin may be warranted, presumably at the facet of GHRH analogues like sermorelin, as in a sermorelin-ipamorelin mix. The lack of knowledge on this space signifies that additional experimentation is warranted with each sermorelin and a sermorelin-ipamorelin mix. To date, ipamorelin has yet to move clinical trials or obtain FDA approval. The only evidence that ipamorelin can stimulate growth hormone (GH) release comes from animal research 12. Ipamorelin is a pentapeptide (a chain of five amino acids) that was developed by Novo Nordisk, a Danish pharmaceutical firm. As a synthetically produced peptide, ipamorelin is chemically much like GHRP-1, the growth hormone-releasing peptide that’s naturally produced within the physique.

Hilda Sargent, 19 years

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This will be certain that you are in a position to maintain enough testosterone ranges within the physique. Excessive or improper use of HGH may trigger acromegaly in some individuals which is overgrowth within the bones and connective tissue. This could lead to alterations in facial options or palms and feet. A combination of proteins and Amino Acids along with PeakATP is sure that will help you slightly within the muscle gaining endeavor. Chromium to make you extra insulin sensitive, Carnitine to assist your metabolism, and varied others to assist your fat loss endeavors.
Over the years, it gained recognition among bodybuilders and athletes because of its capability to extend muscle mass and strength, in addition to decreasing physique fat in the process. Test E is a long-acting steroid that's generally used as a base for most steroid cycles. Its half-life is round eight days, permitting for sustained muscle progress and power features.
Insulin is one other progress hormone within the physique and like cortisol, may cause the physique to store fat. Anavar regulates insulin ranges in order that they don’t rise beyond a certain stage; accelerating fat loss. So in case your cortisol levels are high – you’re going to add body fat in the locations where you actually battle to lose it. For males that is often at the bottom of the abdomen; for women, it’s typically in the hips/legs/bum areas.
Though Winstrol may have an edge on enhancing body composition, its side effects are dramatically worse in comparison with Anavar. Winstrol certainly isn’t protected and is not suitable for novices, whereas Anavar is commonly taken as a primary time cycle. This is predominantly why Anavar is much more well-liked than Winstrol. The reason that so many guys like this compound when they are in a cutting part is that it's going to enable them to retain lean mass whereas also getting stronger and avoiding water retention. If you go longer than that, you're risking excessively high LDL levels of cholesterol. To reduce the chance of virilization even further, ladies may opt to begin taking Anavar at 5mg and improve their dose steadily.
For males, the average cycle spans 6-8 weeks, whereas ladies typically restrict it to 4-6 weeks. Prolonging the cycle beyond these pointers might heighten the chance of unwanted aspect effects, underscoring the significance of accountable and informed use. After finishing a cycle of Anavar, many customers witness a outstanding weight loss transformation. When combined with a balanced diet and regular workout routine, the effect of Anavar on fats loss is usually significant. Despite being much less visible, the impression on the resilience of the physique is noteworthy.
Clenbuterol has potent effects on the central nervous system, causing the body to lift adrenaline production. Consequently, physique temperature increases, and customers enter a state of thermogenesis, successfully accelerating fat loss at relaxation. Real-life results from males utilizing Anavar persistently present important features in muscle mass, power, and general physique composition. Dosage adjustments may be essential primarily based on individual tolerance. Females may also expertise progress in muscle tone and fats loss throughout the same timeframe, but dosages are often adjusted to avoid masculine unwanted effects. Some customers expertise minor unwanted effects, similar to acne or hair loss, but these are typically manageable and short-term. Proper usage and session with a healthcare skilled can help scale back these risks.
There have been no dosage instructions particular to ladies when Anavar was first launched. The only warning was that pregnant women should chorus from utilizing the drug. Roughly a decade after Anavar got here available on the market, there were hopes of it being a drugs to efficiently treat excessive ldl cholesterol. This was due to docs in the ’70s observing reduced whole cholesterol levels in Anavar users (15). A basic rule with steroids is that the more pronounced the outcomes, the more extreme the unwanted side effects are.
For instance, if you wish to reduce, you'll be able to stack Anavar with Winstrol or Trenbolone. Each Winstrol and Trenbolone are dry compounds that don’t aromatize. Not simply this, they're known to boost fat loss while rising lean muscle mass within the physique. Nonetheless, stacking Anavar with Winstrol or Trenbolone can worsen the side effects. An Anavar and Take A Look At Enanthate cycle can yield highly desirable outcomes, encompassing substantial muscle positive aspects and general enhanced efficiency. To wrap up, Anavar brings about simply observable changes to the body that are indicative of its impact.
Each of most of these testosterone has completely different esters, which affect the speed of its delivery. Examine out this unimaginable testosterone cypionate earlier than and after to see the transformation. Crafted with precision, this supplement is a powerhouse of elements like Arginine, strategically designed to stimulate the pure launch of HGH.
HCG is not beneficial for women as a PCT, as it could doubtlessly enlarge the ovaries (26) and trigger virilization (27). Clomid can be not a favorable PCT for girls, as it might trigger the ovaries to turn into oversensitive. Others use tablet cutters to separate 10 mg drugs in half, giving them four x 5 mg doses. If 2.5 mg drugs are obtained, this reduces the need to minimize any of the pills.

Sung Arsenault, 19 years

5 Great Foods For Your Teeth

The calcium in our bodies is crucial for building strong bones and teeth, maintaining healthy muscles, and ensuring the nervous system functions properly. Unfortunately, many of us don’t get enough calcium from our diets—especially if we’re not consuming dairy products or fortified foods regularly. That’s why it’s essential to find reliable sources of calcium that fit your lifestyle. Below are 12 practical options for boosting your calcium intake, whether you prefer plant-based foods, supplements, or fortified items.





Dairy Products


Milk, yogurt, and cheese remain the most straightforward ways to consume calcium. A single cup of milk contains about 300 mg of calcium, while a cup of plain yogurt can offer roughly 350 mg. Opt for low-fat versions if you’re watching your calorie intake, but remember that whole dairy also provides essential vitamins like D.



Fortified Plant Milks


For those who avoid animal products, fortified almond, soy, oat, or rice milks are excellent substitutes. Most brands add around 300–400 mg of calcium per cup—often comparable to dairy milk. Check the label for added vitamin D, which enhances absorption.



Calcium-Rich Leafy Greens


Dark leafy greens such as collard greens, turnip greens, and bok choy contain about 200–250 mg of calcium per cooked cup. While not as high as fortified milks, they also provide fiber, vitamins A and K, and phytonutrients that support overall bone health.



Canned Fish with Bones


Sardines or salmon canned in oil, with edible bones, are an excellent source—one 3.5-ounce can provides roughly 180–200 mg of calcium. They’re also rich in omega‑3 fatty acids and vitamin D, which aid calcium absorption.



Fortified Plant‑Based Milk Alternatives


Soy milk, almond milk, or oat milk that is fortified with calcium (about 300 mg per cup) can replace dairy in smoothies. Pairing them with protein powders and berries yields a nutrient‑dense shake suitable for vegan diets.





Bottom Line




Protein: A plant‑based smoothie can provide ~20–30 g of high‑quality protein when you include a protein powder or nut butter, matching many animal‑derived shakes.


Calcium: To meet the daily 1,000 mg requirement, supplement with fortified milks, tofu, seeds, and leafy greens. Aim for at least 500–800 mg per meal from these sources; additional intake can come from calcium‑rich snacks or supplements if needed.



By thoughtfully combining ingredients—especially fortified plant milks, calcium‑dense vegetables, nuts/seeds, and a protein supplement—you can design a smoothie that rivals the nutritional profile of a traditional animal‑derived milk shake in both protein and calcium content.

Ladonna Mintz, 19 years

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