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Was sind Wachstumshormon-Injektionen?



Wachstumshormon (GH) ist ein körpereigenes Peptid, das von der Hirnanhangdrüse produziert wird. In Form von synthetischem GH kann es als Medikament verabreicht werden, um verschiedene medizinische Zustände zu behandeln. Die Injektion erfolgt in der Regel subkutan, meist einmal täglich oder wöchentlich, je nach Indikation.



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Hauptanwendungen




Erkrankung Ziel der Therapie Häufige Dosierung


Wachstumsstörungen bei Kindern (z. B. GH-Defizienz) Förderung des Knochenwachstums und Erhöhung der Körpergröße 0,3–0,5 µg/kg/Tag


GH-Mangel bei Erwachsenen Verbesserung von Muskelmasse, Knochendichte und Energielevel 2–4 IU/Woche (je nach Bedarf)


Prader-Willi-Syndrom Reduktion von Fettanteil, Steigerung der körperlichen Aktivität 0,3–0,5 µg/kg/Tag


Körperfettabbau bei bestimmten Stoffwechselstörungen Erhöhung des Grundumsatzes individuell angepasst


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Wirkungsmechanismus



GH bindet an spezifische Rezeptoren auf Zellen und aktiviert die Signalwege von Insulin-ähnlichem Wachstumsfaktor-1 (IGF-1). IGF-1 ist für die Zellproliferation, Knochenbildung und den Fettstoffwechsel verantwortlich. Durch diesen Mechanismus wird das Wachstum gefördert und der Stoffwechsel reguliert.



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Häufige Nebenwirkungen




Symptom Häufigkeit Schweregrad


Ödeme (Wasserretention) 20–30 % Leicht bis mäßig


Gelenk- und Muskelschmerzen 15–25 % Mäßig


Kopfschmerzen 10–15 % Leicht


Hyperglykämie (Erhöhung des Blutzuckers) 5–10 % Mild bis schwer


Akromegalie-symptome bei Überdosierung

Leora Murtagh, 19 years
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